Danielle attended the University of Wisconsin-Madison for her undergraduate degree and completed her honors thesis in the lab of Francisco Pelegri. This experience sparked Danielle’s fascination with the microscopic world as she developed a system to visualize microtubule dynamics in developing zebrafish embryos. After graduation, Danielle continued to work in the Pelegri lab as a technician, where she further refined her skills in microscopy and genetics to characterize the localization patterns of the dorsal-axis determinant, glutamate receptor interacting protein 2a.
After spending her adolescence and early adulthood braving frigid Wisconsin winters, Danielle moved to sunny San Diego, California in 2013 to start her graduate work in The Scripps Research Graduate Program in the lab of Gabe Lander. Over the next five years, Danielle enthusiastically seized the opportunity to establish a cryo-electron tomography (cryo-ET) and subtomogram averaging pipeline within the institute, and utilized these techniques to solve the first three-dimensional structure of the large, flexible, multi-subunit cytoplasmic dynein complex bound to microtubules.
In 2018, Danielle received the Harold M. Weintraub Graduate Student Award, completed her PhD, and accepted an independent research position in the Scripps Fellows program. To further enrich her technical capabilities, Danielle completed a short post-doctoral position at the California Institute of Technology (Caltech) in the lab of Grant Jensen to train on cutting-edge instrumentation in the exciting and emerging field of cellular cryo-electron tomography before applying these advanced methodologies to her own independent research.
Danielle returned to Scripps Research in 2019 to start her lab as a faculty member in the Department of Integrative Structural and Computational Biology and received a promotion to Assistant Professor in 2021. Danielle was awarded the Damon Runyon-Rachleff Innovator Award from the Damon Runyon Cancer Foundation in 2021 to study structural mechanisms of mitochondrial fragmentation in cancer. In addition to exciting pursuits in the lab, Danielle is co-director of the Scripps Graduate Cell Biology course, a low-key yogi, a lifelong Deadhead, and a Michael Scott aficionado.
Ben earned his PhD in James Fraser’s lab at UCSF, where he developed software tools for data analysis and validation in structural biology, as well as experimentally investigating the mechanisms by which mammalian chitinases processively hydrolyze the prevalent polysaccharide chitin. Prior to that, as an undergraduate in Elizabeth Sattely’s lab at Stanford University, he investigated bacterial degradation of the polymer lignin. Before joining the Grotjahn lab, he worked at Genentech, where he developed software tools to automate processing of data from single particle cryo-EM.
Ben is interested in understanding how protein structure and function is impacted by cellular contexts. His work in the lab focuses on using in situ cryoelectron tomography to determine both structure and cellular localization in parallel, and to understand how protein structure changes in different cellular environments. He is particularly interested the regulation and function of proteins that polymerize in cells.
Outside of research, he is obsessed with finding the perfect cup of coffee, a quest that has included learning to roast his own coffee beans.
Ben is supported by a postdoctoral fellowship from the American Cancer Society.
Hamid got his BSc in Physics from University of Tehran in Iran. He went to FSU for his PhD where he worked on Ultrafast Electron Diffraction before moving to cryoEM field in Kenneth Taylor’s Lab.
His PhD was focused on the myosin coiled coil structure from the giant water bug (Lethocerus indicus) using single particle reconstruction and he is very pround of his de novo, 1600A long atomic model 7KOG.
He joined the Grotjahn lab as a postdoc to learn cryo-electron tomography and in situ studies of mitochondrial membrane. He is interested in understanding the molecular interactions that mediate membrane constriction as well as the topology of mitochondrial membrane-embedded proteins.
Outside of research, Hamid enjoys running, reading, and Iranian music.
Michaela received her undergraduate degree in Biochemistry and Cell Biology from the University of California, San Diego. She conducted her undergraduate and post-baccalaureate research at the Salk Institute in the lab of Dmitry Lyumkis. In the lab, she utilized biochemical and single particle cryogenic electron microscopy techniques to better understand the process of gamma retroviral integration.
Michaela joined the Grotjahn Lab at the Scripps Research Institute for her PhD, where she is interested in using the cellular cryogenic electron tomography to investigate the morphological changes in mitochondria in response to cellular stress.
Outside of lab, Michaela is a classically trained double bassist, an avid reader, a weekend hiker, and a foodie.
Dan earned his undergraduate degree in Biochemistry from California State University, Los Angeles. He completed his honors thesis in the Zurita-Lopez lab, studying histone tail post-translational modifications using biochemical techniques. He then went on to work as a research assistant in the Rodriguez lab at University of California, Los Angeles. There, he utilized structural and biochemical techniques to study broadly neutralizing antibodies against New World Hemorrhagic Fever Arena Viruses.
Dan is now a joint PhD student in the Grotjahn and Wiseman Labs at Scripps Research Institute, where he uses cryo-electron tomography and biochemical approaches to investigate the molecular mechanisms that regulate mitochondrial morphology in response to cellular stress.
Outside of research, Dan enjoys skating, photography, grubbing with the homies, and hanging out with his cat and doggo.
Marina earned her BSc in Cellular and Molecular Biology from the University of La Verne and graduated from the Honors Program. She conducted her senior thesis research in the lab of Stacey Darling-Novak where she studied first leaf formation in S. plicata identifying novel auxin-mediated genes.
Marina spent four years in industry at Lumos Diagnostics, Cibus and the San Diego County Public Health Lab before joining the Grotjahn and Williamson labs. The labs began their collaboration in 2019 and Marina is currently using cryo-electron tomography to visualize ribosomal intermediates in E.coli. She is also an aspiring plant biologist applying to PhD programs.
Outside of research, Marina loves to spend time with her cats, make pies, camp, compost, and grow odd vegetables.